Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
Katarzyna Niemirowicz-Laskowska1, Katarzyna Głuszek1, Ewelina Piktel1
1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland.
Background:
1,4-Dihydropyridine (1,4-DHP) and its derivatives are well-known calcium channel blockers with antiarrhythmic and antihypertensive activities. These compounds exhibit pleiotropic effects including antimicrobial activities that rely on their positive charge and amphipathic nature. Use of magnetic nanoparticles (MNPs) as carriers of 1,4-DHP modulates their properties and enables improved formulations with higher efficacy and less toxicity.
Methods:
In this study, the antimicrobial and immunomodulatory activities of novel 1,4-DHP derivatives in free form and immobilized on MNPs were determined by evaluating pathogen outgrowth and proinflammatory cytokine release in experimental settings that involve incubation of various 1,4-DHPs with clinical isolates of bacteria or fungi as well as mammalian cell culture models.
Results:
Conventional immobilization of 1,4-DHP on aminosilane-coated MNPs markedly enhances their antimicrobial activity compared to nonimmobilized molecules, in part because of the higher affinity of these nanosystems for bacterial cell wall components in the presence of human body fluids.
Conclusion:
Optimized nanosystems are characterized by improved biocompatibility and higher anti-inflammatory properties that provide new opportunities for the therapy of infectious diseases.
Related Concept Videos
01:29Properties of Continuous Functions
02:58Properties of Transition Metals
02:57Physical and Chemical Properties of Matter
03:02Colors and Magnetism
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
01:18Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
01:14Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene