Related Experiment Video

Updated: Feb 8, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.7K

Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer

Guoyu Huang1, Guanbao Zhu1

  • 1Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China.

Oncotargets and Therapy
|June 22, 2018
PubMed

Insights

Sirtuin 4 (SIRT4) plays a complex role in cancer, acting as both an oncogene and tumor suppressor. This review explores SIRT4

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Genetics

Background:

  • Sirtuins (SIRTs) are NAD+-dependent enzymes involved in cellular regulation.
  • Members of the SIRT family exhibit diverse roles in tumorigenesis, either promoting or suppressing tumor development.
  • SIRT4's specific function in cancer remains incompletely understood.

Purpose of the Study:

  • To review recent advancements regarding SIRT4 in the context of cancer.
  • To investigate the multifaceted relationship between SIRT4 and various tumor types.
  • To evaluate SIRT4's potential as a therapeutic target for cancer treatment.

Main Methods:

  • Literature review of recent studies on SIRT4 and cancer.
  • Analysis of SIRT4's dual role as an oncogene and tumor suppressor.
  • Exploration of SIRT4's mechanistic pathways in tumorigenesis.

Main Results:

  • SIRT4 exhibits context-dependent functions in cancer, acting as both an oncogene and a tumor suppressor.
  • Evidence suggests SIRT4 influences key cellular processes relevant to cancer progression.
  • Understanding SIRT4's mechanism is crucial for its therapeutic application.

Conclusions:

  • SIRT4's complex role in cancer necessitates further investigation.
  • SIRT4 presents a potential, albeit complex, therapeutic target in oncology.
  • Targeting SIRT4 may offer novel strategies for cancer therapy.
Keywords:
SIRT4cancergenetic instabilitymetabolismsirtuin

More Related Videos

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.2K
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

5.9K

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K
Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch01:15

Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch

The history of therapeutic communication can be traced back to Florence Nightingale, who emphasized the importance of developing trusting relationships with patients. She taught that the presence of nurses with patients results in therapeutic healing.
Therapeutic communication is not the same as social interaction. Social interaction has no goal or purpose and consists of casual information sharing, whereas therapeutic communication has a plan or purpose for the conversation. Therapeutic...
8.0K