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Updated: Feb 8, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
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The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

Tongwen Ou1, Michael Lilly2, Wei Jiang3,4

  • 1Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Frontiers in Immunology
|June 22, 2018
PubMed

Insights

Toll-like receptor 4 (TLR4) is present in prostate cells and influences cancer. This review explores TLR4

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Toll-like receptor 4 (TLR4) is expressed on normal and malignant prostate epithelial cells.
  • TLR4 signaling mediates innate immune responses against pathogens.
  • Increased TLR4 expression is observed in prostate cancer tissues.

Purpose of the Study:

  • To review the key features of the TLR4 signaling pathway and its immune responses.
  • To focus on the pathological role of TLR4 in prostate carcinogenesis and tumor progression.

Main Methods:

  • Literature review of studies on TLR4 signaling in prostate cancer.
  • Analysis of the dual role of TLR4 in cancer development and anti-tumor effects.

Main Results:

  • TLR4 signaling pathways are involved in innate immunity.
  • Altered TLR4 signals in prostate cancer can promote tumorigenesis.
  • TLR4 also exhibits anti-tumor effects in the context of prostate cancer.

Conclusions:

  • TLR4 plays a complex and significant role in prostate cancer.
  • Understanding TLR4's function is crucial for developing targeted therapies.
Keywords:
bacteriacarcinogensinflammationprostate cancertoll-like receptor 4

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