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Updated: Feb 8, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
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Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

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CD73 expression and clinical significance in human metastatic melanoma

Inês Monteiro1, Selena Vigano2, Mohamed Faouzi3

  • 1Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Oncotarget
|June 22, 2018
PubMed
Abstract

Insights

CD73 expression in tumor cells correlates with worse survival in melanoma, but CD73 in immune cells suggests better outcomes. These findings support exploring anti-CD73 therapies for metastatic melanoma.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • CD73 is an ectoenzyme that produces adenosine.
  • It plays roles in immune suppression and tumor growth.
  • CD73 is a potential target for immuno-oncology therapies.

Purpose of the Study:

  • To investigate CD73 expression in metastatic melanoma.
  • To determine the association between CD73 expression and patient survival.

Main Methods:

  • Immunohistochemistry was used to assess CD73 expression in 114 metastatic melanoma patients.
  • Evaluated CD73 in tumor cells (TC) and tumor-infiltrating mononuclear cells (TIMC).

Main Results:

  • CD73 was detected in 54% of metastatic melanomas.
  • CD73 in TC correlated with decreased overall survival (OS).
  • CD73 in TIMC correlated with improved OS.

Conclusions:

  • CD73 expression has opposing prognostic roles in melanoma based on its location (TC vs. TIMC).
  • Results support further investigation of anti-CD73 therapies for metastatic melanoma.
Keywords:
CD73ecto-5'-nucleotidaseimmunohistochemistrymelanomaprognosis

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