Related Experiment Video

Updated: Feb 8, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target

Mu Yao1, Linda Rogers2, Natalka Suchowerska2

  • 1Central Clinical School and Charles Perkins Centre, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|June 23, 2018
PubMed

Insights

Targeting DNA repair pathways can sensitize prostate cancer cells to radiation therapy. This approach aims to improve treatment outcomes by preventing cancer recurrence after irradiation.

Area of Science:

  • Oncology
  • Radiation Biology
  • Molecular Biology

Background:

  • Radiation therapy is a cornerstone of cancer treatment, inducing DNA damage to eliminate malignant cells.
  • Cancer cell survival post-irradiation contributes to disease progression and recurrence.
  • Aberrant DNA damage repair pathways in cancer cells influence their response to radiation therapy.

Purpose of the Study:

  • To review recent findings on molecular targets and pathways for sensitizing prostate cancer cells to ionizing radiation.
  • To explore strategies for improving therapeutic outcomes in prostate cancer treatment.

Main Methods:

  • Literature review of recent research on DNA damage repair pathways in prostate cancer.
  • Analysis of molecular targets and signaling pathways involved in radioresistance.
  • Focus on strategies to enhance the efficacy of ionizing radiation.

Main Results:

  • Identified key molecules and pathways that can be targeted to overcome radioresistance in prostate cancer.
  • Highlighted the role of altered DNA damage repair in modulating radiation response.
  • Provided insights into potential therapeutic strategies for improved outcomes.

Conclusions:

  • Targeting specific molecules and pathways involved in DNA repair presents a promising strategy to sensitize prostate cancer to radiation.
  • Enhancing the radiosensitivity of prostate cancer cells can lead to improved therapeutic efficacy and reduced recurrence.
  • Further research into these targets may pave the way for novel combination therapies.
Keywords:
DNA damageDNA repairProstate cancerRadiation

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.6K
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.6K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.8K
C4 Pathway and CAM01:27

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
Absorption of Radiation01:05

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.3K