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Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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Hypothermic Machine Perfusion Results in a Marginal Kidney Transplant Programme
Victoria Gómez-Dos Santos1, Mercedes Ruiz Hernández1, Francisco Javier Burgos-Revilla1
1Urology Department, Ramón y Cajal University Hospital, Surgical Urology and Transplantation Research Group, IRYCIS, Alcalá University, Madrid, Spain.
European Urology Focus
|June 23, 2018
Summary
Donor category, not origin, impacts kidney transplant outcomes with hypothermic machine perfusion (HMP). Donor after circulatory death (DCD) category significantly affects delayed graft function and graft survival in HMP kidney transplants.
Area of Science:
- Nephrology
- Transplantation immunology
- Organ preservation
Background:
- Hypothermic machine perfusion (HMP) improves outcomes for deceased donor kidneys compared to static cold storage, especially for marginal donors.
- Evidence is limited regarding the influence of graft center of origin and donor category on HMP efficacy.
Purpose of the Study:
- To identify factors influencing hypothermic machine perfusion (HMP) outcomes in kidney transplantation from marginal donors.
- To investigate the impact of donor category and graft center of origin on HMP results.
Main Methods:
- Analysis of prospectively collected data from 214 adult recipients of first kidney transplants using expanded criteria donors (ECD) and donors after circulatory death (DCD) categories II and III.
- Assessment of delayed graft function (DGF) and graft survival (GS) using logistic and Cox regression analyses.
Main Results:
- Donor category (specifically DCD) and pre-transplant hemodialysis were significantly associated with DGF development.
- Donor category and donor age were identified as independent predictors of graft survival (GS).
- Graft center of origin did not significantly impact DGF or GS in HMP kidney transplants.
Conclusions:
- Donor category, particularly DCD, significantly influences delayed graft function and graft survival in hypothermic machine perfusion of deceased donor kidneys.
- Graft center of origin does not appear to be a significant factor affecting HMP outcomes.
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