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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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1,3-Di(quinolin-2-yl)guanidine binds to GGCCCC hexanucleotide repeat DNA in C9ORF72

Tomonori Shibata1, Eitaro Murakami1, Kazuhiko Nakatani1

  • 1Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.

Bioorganic & Medicinal Chemistry Letters
|June 23, 2018
PubMed

Keywords:
DNA-binding small moleculeGGCCCC hexanucleotide repeatsMismatched base pair

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