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Published on: July 21, 2016
Maternal weight and infections in early childhood: a cohort study
Samuel Videholm1,2, Sven-Arne Silfverdal1, Georges Reniers3,4
1Department of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Insights
Maternal overweight and obesity during pregnancy increase the risk of hospitalizations for infectious diseases in early childhood. This includes a notable association with perinatal infections, highlighting the importance of maternal health for infant well-being.
Area of Science:
- Public Health
- Epidemiology
- Pediatrics
Background:
- Maternal pre-pregnancy weight is a significant factor influencing pregnancy outcomes and infant health.
- Understanding the link between maternal weight and childhood infectious diseases is crucial for preventative strategies.
Purpose of the Study:
- To investigate the association between maternal weight status during pregnancy and the incidence of infectious disease hospitalizations in early childhood.
- To explore specific categories of infectious diseases linked to maternal weight.
Main Methods:
- A population-based cohort study utilizing national Swedish registers.
- Inclusion of over 693,000 children born between 1998 and 2006.
- Analysis of hospitalizations for various infectious diseases within the first five years of life.
Main Results:
- Overweight and obesity in pregnancy were associated with a higher overall incidence of infectious disease hospitalizations (IRR 1.05 and 1.18, respectively).
- A strong association was observed between maternal overweight/obesity and perinatal infections (IRR 1.34 and 1.72, respectively).
- No significant association was found for skin, soft tissue, neurological, digestive, or bloodstream infections.
Conclusions:
- Maternal overweight and obesity during pregnancy are linked to an increased risk of infectious disease hospitalizations in early childhood.
- The findings underscore the importance of managing maternal weight for preventing childhood infections, particularly perinatal ones.
Objective:
The aim of this study was to examine this association between maternal weight during pregnancy and the incidence of hospitalisations for infectious diseases during early childhood.
Design:
A population-based cohort study.
Setting:
A national cohort was created by combining data from the Swedish Medical Birth Register, the National Inpatient Register, the Cause of Death Register, the Total Population Register and the Longitudinal integration database for health insurance and labour market studies.
Patients:
693 007 children born in Sweden between 1998 and 2006.
Main Outcome Measures:
Number of hospitalisations for infectious diseases during the first 5 years of life, overall and for categories of infectious diseases (lower respiratory, enteric, upper respiratory, genitourinary, perinatal, skin and soft tissue, neurological and eye, digestive tract, bloodstream and other infections).
Results:
Overweight (body mass index (BMI) 25.0-29.9) and obesity (BMI≥30) during pregnancy were associated with a higher overall incidence of hospitalisations for infectious diseases, adjusted incidence rate ratio (IRR) 1.05 (95% CI 1.03 to 1.06) and adjusted IRR 1.18 (95% CI 1.16 to 1.21). Overweight and obesity during pregnancy were strongly associated with perinatal infections, adjusted IRR 1.34 (95% CI 1.25 to 1.44) and adjusted IRR 1.72 (95% CI 1.57 to 1.88). In contrast, we found no association between maternal weight during pregnancy and infections of skin and soft tissue, the nervous system, the digestive tract or the bloodstream.
Conclusions:
We observed an association between overweight and obesity during pregnancy, and hospitalisations for infectious diseases during early childhood.
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