Related Experiment Video
Updated: Feb 8, 2026

Assessing Disaster Resilience of Concrete with Titanium Dioxide Nanoparticles
Published on: November 14, 2025
Titanium dioxide in dental enamel as a trace element and its variation with bleaching
Tatiana Vargas-Koudriavtsev1, Randall Durán-Sedó2, Óscar-Andrey Herrera-Sancho3
1Dental Faculty, University of Costa Rica. Postgraduate Program in Prosthodontics, University of Costa Rica.
Tooth bleaching agents affect titanium dioxide concentration in dental enamel. In-office whitening increased titanium dioxide, while at-home bleaching reduced it, impacting enamel properties.
Area of Science:
- Dental materials science
- Biomaterials research
- Spectroscopic analysis
Background:
- Titanium dioxide (TiO2) is a trace element in dental enamel with implications for enamel color and crystal structure.
- Limited research exists on the interaction between dental bleaching agents and titanium dioxide concentration in enamel.
Purpose of the Study:
- To investigate the impact of various tooth bleaching agents on titanium dioxide concentration within dental enamel.
- To utilize confocal Raman spectroscopy for precise analysis of titanium dioxide levels before and during whitening procedures.
Main Methods:
- Human teeth were divided into six groups and subjected to different bleaching protocols.
- Confocal Raman spectroscopy was employed to identify and quantify titanium dioxide in enamel.
- Statistical analysis involved repeated measures ANOVA and Bonferroni pairwise comparisons.
Main Results:
- In-office whitening products significantly increased titanium dioxide concentration in enamel (p≤0.05).
- Longer bleaching protocols, such as at-home bleaching gels, negatively affected titanium dioxide concentration, leading to a loss.
- All tested dental specimens showed the presence of titanium dioxide as a trace element.
Conclusions:
- Tooth bleaching protocols differentially affect titanium dioxide concentration in dental enamel.
- Short-term, high-concentration in-office bleaching increases titanium dioxide, whereas long-term, low-concentration at-home bleaching decreases it.
- The findings highlight the importance of considering trace element alterations during dental whitening procedures.
Related Concept Videos
Elements and Compounds
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
What is Variation?
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
Elements: Chemical Symbols and Isotopes
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
The Periodic Table and Organismal Elements
Periodic Classification of the Elements
Classification of Elements and Compounds
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...

