Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...

Structural Protein Function

Structural Protein Function

Protein and Protein Structures

Protein and Protein Structures

Viral Structure

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Current status of -omics research in platyhelminth parasites of teleost fish.

Advances in parasitology·2026

Same author

Comparative metagenomic analysis of microbial communities: unravelling microbial communities from the great Rann of Kachchh and coastal saltpans, Gujarat, India.

Extremophiles : life under extreme conditions·2026

Same author

Protecting valuable stock: Non-lethal sampling approaches for Cardicola spp. monitoring in ranched Southern bluefin tuna.

Veterinary parasitology·2026

Same author

Harnessing Bacterial Lipid Coatings on Gold Nanoparticles for Enhanced Cell Adhesion Applications.

Small science·2026

Same author

Predicting the Impact of Glycosylation on the Structure and Thermostability of <i>Helicobacter pylori</i> Blood Group Binding Adhesin.

Biomolecules·2025

Same author

Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase.

PLoS pathogens·2025

Search research articles

Related Experiment Video

Updated: Feb 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

BioStructMap: a Python tool for integration of protein structure and sequence-based features.

Andrew J Guy^1,2, Vashti Irani^1,3, Jack S Richards^1,3,4,5

¹Life Sciences, Burnet Institute, Melbourne, VIC, Australia.

Bioinformatics (Oxford, England)

|June 23, 2018

Summary

This summary is machine-generated.

BioStructMap is a new Python tool enabling 3D sliding window analysis on protein structures. It links genomic sequences to protein structures for genetic analysis, aiding studies on structural selection pressures.

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Feb 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Area of Science:

Computational Biology
Structural Bioinformatics
Genomics

Background:

Sliding window analysis is a standard technique for sequence data.
Analyzing protein structures in 3D space requires specialized tools.
Linking genomic information to protein structure can reveal functional insights.

Purpose of the Study:

To introduce BioStructMap, a Python tool for 3D sliding window analysis of protein structures.
To enable the mapping of genomic sequences to protein structures.
To facilitate genetic-based analysis on spatially linked codons within protein structures.

Main Methods:

Development of the BioStructMap Python package.
Implementation of a 3D sliding window approach for protein structures.
Integration of functionality for mapping genomic sequences to protein structures.

Main Results:

BioStructMap extends sequence analysis to 3D structural data.
The tool allows for custom function application on spatially aggregated data.
It enables genetic analysis directly on protein structural elements.

Conclusions:

BioStructMap provides a novel method for analyzing protein structures in 3D.
The tool has significant applications in understanding selection pressures at the protein structure level.
BioStructMap enhances the integration of structural and genomic data analysis.