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Related Concept Videos

Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Data Reporting and Recording01:24

Data Reporting and Recording

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Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
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Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

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Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
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Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

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In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
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Coagulation Abnormalities Following NexoBrid Use: A Case Report.

Nuria Martín1, Patricia Guilabert1, Luis Abarca1

  • 1Anesthesia and Critical Care Department and Burn Center, Barcelona, Spain.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|June 23, 2018
PubMed
Summary

Major burn patients experience coagulation changes. A case study reveals a potential link between NexoBrid, a bromelain-based eschar removal agent, and coagulation abnormalities in burn patients.

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Area of Science:

  • Burn injury pathophysiology
  • Coagulation disorders
  • Wound healing therapeutics

Background:

  • Major burn injuries trigger systemic inflammatory responses and coagulation abnormalities, similar to sepsis or trauma.
  • Approximately 40% of major burn patients exhibit altered standard coagulation tests, influenced by burn severity, smoke inhalation, and fluid resuscitation.
  • Aggressive surgical debridement for burn lesions can lead to significant blood loss.

Observation:

  • NexoBrid, an enzymatic debriding agent derived from bromelain, is indicated for eschar removal in deep thermal burns.
  • While oral bromelain's hemostatic effects are noted, NexoBrid's clinical impact on coagulation remains unclear.
  • A clinical case presented a patient with burns who developed a coagulation abnormality post-NexoBrid application.

Findings:

  • The study highlights a potential association between NexoBrid use and the development of coagulation abnormalities in burn patients.
  • This observation warrants further investigation into the hemostatic effects of topical bromelain-based agents in clinical settings.
  • Coagulation monitoring may be crucial in burn patients treated with NexoBrid.

Implications:

  • Understanding NexoBrid's hemostatic impact is vital for managing burn patients and optimizing treatment protocols.
  • This case underscores the need for vigilance regarding potential side effects of novel wound care agents.
  • Further research is needed to elucidate the precise mechanisms and clinical significance of NexoBrid-induced coagulation changes.