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Antibiotic Selection00:57

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Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
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Can epilepsy be treated by antibiotics?

Hilde M H Braakman1, Jakko van Ingen2

  • 1Department of Neurology, Academic Center for Epileptology, Kempenhaeghe & Maastricht UMC+, Sterkselseweg 65, 5591 VE, Heeze, The Netherlands. braakmanh@kempenhaeghe.nl.

Journal of Neurology
|June 23, 2018
PubMed
Summary

Antibiotic treatment temporarily reduced seizures in six epilepsy patients by disrupting the gut microbiota. This suggests gut-brain interactions may influence epilepsy, offering potential new treatment avenues for drug-resistant cases.

Keywords:
AntibioticsEpilepsyKetogenic dietMicrobiome

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Area of Science:

  • Neurology
  • Microbiology
  • Gastroenterology

Background:

  • Emerging evidence links gut microbiota and gut-brain interactions to neurological disorders.
  • Six patients with drug-resistant epilepsy experienced temporary seizure freedom with antibiotic therapy.

Discussion:

  • Antibiotic treatment transiently altered seizure frequency, suggesting a microbiota-mediated effect.
  • The impact diminished within two weeks of antibiotic cessation, indicating a short-term influence.
  • This highlights the potential role of gut microbiota in epilepsy pathophysiology.

Key Insights:

  • Gut microbiota disruption by antibiotics may temporarily modulate gut-brain interactions.
  • This modulation appears to influence seizure frequency in epilepsy patients.
  • The findings suggest a potential link between gut health and epilepsy management.

Outlook:

  • Investigating gut microbiota alterations as a therapeutic strategy for drug-resistant epilepsy.
  • Further research into the mechanisms connecting gut-brain axis and seizure control.
  • Exploring non-antibiotic interventions targeting the gut microbiota for epilepsy treatment.