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Mycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5): A Case Series

Hazal Boral1, Anne van Diepeningen2, Elif Erdem3

  • 1Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, 01330, Adana, Turkey.

Mycopathologia
|June 23, 2018
PubMed

Insights

Mycotic keratitis caused by Fusarium solani is increasing globally. Early diagnosis and treatment with topical amphotericin B and voriconazole led to successful recovery in three patients.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Mycotic keratitis, particularly Fusarium infections, poses a significant global health challenge, leading to preventable corneal blindness.
  • Inadequate diagnosis and treatment contribute to poor outcomes and rising infection rates worldwide.

Observation:

  • Three cases of Fusarium solani sensu stricto (FSSC5) keratitis following ocular trauma were reported from Turkey and The Netherlands.
  • FSSC5 demonstrated low minimum inhibitory concentrations (MICs) for amphotericin B (1 µg/mL) and high MICs for voriconazole (8 µg/mL).

Findings:

  • FSSC5 was identified as the etiological agent using partial tef1-α gene sequencing.
  • Successful treatment was achieved using topical amphotericin B and voriconazole, resulting in complete patient recovery.

Implications:

  • This study highlights the importance of accurate etiological diagnosis in managing Fusarium keratitis.
  • Effective therapeutic strategies involving topical amphotericin B and voriconazole can lead to favorable outcomes in challenging cases of fungal eye infections.
Keywords:
Amphotericin BChlorhexidine gluconateKeratomycosisSoft contact lensesVoriconazole

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