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Neurological and Psychological Changes in Hemodialysis Patients Before and After the Treatment

Silvia Lai1, Alessio Molfino1, Oriano Mecarelli2

  • 1Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|June 23, 2018
PubMed

Insights

Chronic kidney disease patients undergoing hemodialysis show persistent neurological and cognitive changes. While electroencephalogram abnormalities slightly reduced post-hemodialysis, significant differences remained compared to healthy controls.

Area of Science:

  • Nephrology
  • Neuroscience
  • Psychology

Background:

  • Chronic kidney disease (CKD) is associated with neurological, psychological, and cognitive impairments.
  • These disorders significantly impact patients' quality of life.

Purpose of the Study:

  • To evaluate electroencephalographic (EEG), psychological, and cognitive changes in hemodialysis (HD) patients before and after treatment.
  • To compare these changes with healthy controls (HC).

Main Methods:

  • Enrolled 16 HD patients and 15 HC.
  • Assessed EEG, Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Satisfaction Profile (SAT-P), and Neuropsychological test Global z-scores (NPZ5) before (T0) and after (T1) HD.
  • Evaluated renal function, inflammatory markers, and mineral metabolism.

Main Results:

  • HD patients showed significant EEG differences in Beta, Delta, and Theta bands, and the Theta/Alpha index compared to HC at T1.
  • HD patients exhibited significant differences in MMPI-2, SAT-P, and NPZ5 memory and concentration tests compared to HC.
  • EEG abnormalities tended to decrease post-HD, but differences persisted compared to HC.

Conclusions:

  • Hemodialysis patients exhibit persistent psychocognitive alterations correlated with reduced quality of life, mineral metabolism, and inflammation.
  • Further studies with larger HD populations are needed to confirm these findings and assess modifications in EEG and psychocognitive parameters.

Keywords:
Chronic kidney diseaseElectroencephalogramHemodialysisNeurological complicationsPsychological disordersQuality of life

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