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Updated: Feb 8, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
Metabolic characterization of plasma samples in HIV-1-infected individuals
Ting Zhang1, Jianping Sun2, Haiwei Du1
1MOH Key Laboratory of Systems Biology of Pathogen, Institute of Pathogen Biology, China Academy of Medical Sciences & Peking Union Medical College, 6 Rong Jing Dong Jie, Beijing 100176, China.
Aim:
To identify potential biomarkers for the diagnosis and monitoring of HIV-1 progression.
Methods:
19 subjects, diagnosed with HIV-1 infection in the follow-up, prospective, clinical cohort more than 6000 subjects from 2006, were incorporated into our study. The subjects included ten non-progressors and nine rapid progressors. The plasmas of subjects before HIV-1 seroconversion and after seroconversion were collected and analyzed with nontargeted metabolomics.
Results:
20:0-Glc-Campesterol and A-norgorgostanol could significantly distinguished after HIV-1 seroconversion from before HIV-1 seroconversion. PG(O-18:0/18:0) could totally distinguish the plasma of rapid progressor before seroconversion from that of nonprogressor before seroconversion.
Conclusion:
20:0-Glc-Campesterol, A-norgorgostanol and PG(O-18:0/18:0) could be potential biomarkers for the diagnosis and monitoring of HIV-1 progression.
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