Related Experiment Video

Updated: Feb 8, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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MicroRNAs in prostate cancer: From function to biomarker discovery

Ahmed A Moustafa1, Hogyoung Kim2, Rasha S Albeltagy1

  • 11 Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo 11790, Egypt.

Experimental Biology and Medicine (Maywood, N.J.)
|June 23, 2018
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are crucial in prostate cancer development. This review explores miRNA roles in prostate tumorigenesis and their potential as cancer biomarkers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • They influence key cellular processes like proliferation, apoptosis, differentiation, and tumorigenesis.
  • Dysregulation of miRNAs is implicated in various cancers, including prostate cancer.

Purpose of the Study:

  • To review current literature on miRNA biogenesis and function in prostate cancer.
  • To elucidate the interactions between miRNAs, their mRNA targets, and pathways in prostate tumorigenesis and progression.
  • To explore the potential of miRNAs as diagnostic and prognostic biomarkers for prostate cancer.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of miRNA biogenesis and regulatory mechanisms.
  • Examination of miRNA involvement in prostate cancer pathways.
  • Assessment of miRNA potential as biomarkers.

Main Results:

  • miRNAs are critical regulators of gene expression impacting prostate cancer.
  • Specific miRNAs and their target mRNAs are involved in prostate tumorigenesis and progression.
  • Emerging evidence highlights miRNAs as promising biomarkers for prostate cancer detection and monitoring.

Conclusions:

  • miRNAs play significant roles in the molecular network of prostate cancer.
  • Understanding miRNA-mRNA interactions is vital for deciphering prostate cancer biology.
  • miRNAs hold considerable promise for clinical applications in prostate cancer management.
Keywords:
Prostate cancerbiomarkersmicroRNAonco-miRtumor suppressor miRNAs

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