POLYMORPHISM OF COLLECTION, TRANSFUSION AND EFFECTIVENESS OF DONOR PLATELETS CONCENTRATES

Area of Science:

• Hematology
• Transfusion Medicine

Background:

• Platelet transfusions are critical for managing bleeding risks, particularly in patients with hematological disorders or undergoing intensive treatments.
• Current practices in platelet transfusion vary significantly across institutions, impacting patient care and resource allocation.

Purpose of the Study:

• To analyze and compare the practices of platelet transfusions across multiple centers.
• To evaluate the adherence to evidence-based guidelines for prophylactic platelet transfusions.

Main Methods:

• A retrospective analysis of 520 platelet transfusions from 8 different centers.
• Data collection on transfusion indications, patient characteristics, target platelet counts, and preparation methods.

Main Results:

• Prophylactic platelet transfusions were administered 3.6 times more often than for active bleeding.
• 67.5% of recipients had oncology diseases.
• 25% of prophylactic transfusions were given to patients with platelet counts ≥30 x 10⁹/L, exceeding recommended thresholds.
• Apheresis platelet concentrates were used in 76.7% of transfusions, and single-donor units were used more frequently than pooled platelets.

Conclusions:

• Significant variation exists in prophylactic platelet transfusion practices, with frequent administration in oncology patients.
• Current transfusion targets for prophylaxis may be set higher than evidence-based recommendations.
• Apheresis and single-donor units are the predominant methods for platelet concentrate preparation and administration.