Related Experiment Video
Updated: Feb 8, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Lower-Extremity Osteomyelitis Treatment Using Calcium Sulfate/Hydroxyapatite Bone Void Filler with Antibiotics
Background:
Over a 74-month period (∼6 years), 143 lower-extremity osteomyelitis locations in 125 patients were treated with a calcium sulfate/hydroxyapatite liquid bone void filler with antibiotic(s).
Methods:
The osteomyelitis locations were treated with a percutaneous antibiotic delivery technique delivering intraosseous antibiotic followed by either oral or intravenous antibiotics for 4 weeks.
Results:
There was no recurrence of osteomyelitis in 96.15% of the treatable patients. Outcomes classified by the Cierny-Mader clinical classification are discussed as well.
Conclusions:
A bone void filler with antibiotic(s) using the percutaneous antibiotic delivery technique is a safe, reliable, and effective means to treat lower-extremity osteomyelitis with either oral or intravenous antibiotics for 4 weeks.
Related Concept Videos
Imaging Studies VI: Voiding Cystourethrography and Cystography
Additives and Fillers in Concrete
The...
Antibiotic Selection
Total Voids in Concrete
Sulfate Attack on Concrete
Sulfates from sources like soil, groundwater, or industrial effluents...
Absolute and Local Extreme Values

