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Gallbladder cancer - no improvement in survival over time in a Swedish population

Per Lindnér1, Erik Holmberg2, Lo Hafström1

  • 1a Transplant Institute, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden.

Acta Oncologica (Stockholm, Sweden)
|June 23, 2018
PubMed

Insights

Gallbladder cancer (GBC) survival remains poor despite improved diagnostics. While stage migration occurred, leading to better survival for some, overall GBC outcomes did not significantly improve between 2000-2014.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Epidemiology

Background:

  • Gallbladder cancer (GBC) is associated with a very poor prognosis.
  • Understanding trends in GBC incidence, treatment, and survival is crucial for improving patient outcomes.

Purpose of the Study:

  • To analyze trends in GBC incidence, diagnosis, treatment, and overall survival.
  • To evaluate changes in GBC patient outcomes over a 15-year period in a defined Swedish region.

Main Methods:

  • A population-based cohort study of 546 individuals diagnosed with GBC between 2000 and 2014.
  • Patients were categorized into three 5-year periods to assess changes in survival, diagnosis, staging, grading, and treatment.
  • Exclusion criteria included patients deceased at diagnosis and those with non-invasive cancer.

Main Results:

  • GBC incidence remained stable; however, there was a significant stage migration towards more advanced M1 disease.
  • Median survival showed a slight increase from 4.7 months to 6.1 months across the study periods.
  • Surgical outcomes improved, with better survival observed after liver bed resection compared to cholecystectomy alone, despite increased chemotherapy use with no significant survival impact.

Conclusions:

  • Despite advancements in diagnostic methods and evidence of stage migration, overall GBC survival rates did not improve significantly.
  • The study highlights the need for novel therapeutics to downsize tumors and enhance the efficacy of curative-intent surgery for GBC.
Abstract

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