Genital Paget's disease and urinary tract malignancy

Area of Science:

• Urology
• Dermatology
• Oncology

Background:

• Paget's disease of the genital mucosa is a rare intraepithelial adenocarcinoma.
• Its association with lower urinary tract malignancies is not well-established.

Purpose of the Study:

• To describe cases of Paget's disease of the genital mucosa co-occurring with lower urinary tract malignancies.
• To investigate the relationship and potential origins of these conditions.

Main Methods:

• Case series review of eight patients.
• Histopathological analysis of lesions.
• Clinical data review.

Main Results:

• Five cases showed concurrent malignancies.
• One case demonstrated Paget's disease extension from genital mucosa to urethra and bladder.
• Two cases showed pagetoid spread from bladder malignancy to genital mucosa.

Conclusions:

• Genital Paget's disease may be associated with or arise from lower urinary tract malignancies.
• Paget cells may originate from urothelium or epidermal spread.
• Further research is needed to clarify the significance and management.