Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Half-life of a Reaction02:42

Half-life of a Reaction

39.2K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.2K
Characteristics of Life01:23

Characteristics of Life

262.3K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
262.3K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

72.7K
Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.7K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.9K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between salivary neuropeptide Y and performance under stress: a study on police firearms officers.

Frontiers in human neuroscience·2026
Same author

The role of maternal prenatal attachment and postnatal stress on mother-infant bonding at 6 months.

Journal of reproductive and infant psychology·2026
Same author

Exploring the roles of conserved context-dependent cis-regulatory elements (cdCREs) in multicellularity, human health and disease.

The FEBS journal·2025
Same author

Depression in older adults and its associations with sleep and synaptic density.

Journal of affective disorders·2024
Same author

Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study.

Research square·2024
Same author

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.

Nature communications·2024

Related Experiment Video

Updated: Feb 8, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

11.3K

Epigenetic Programming by Early-Life Stress.

Reema Abdulrahman S Alyamani1, Chris Murgatroyd1

  • 1School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom.

Progress in Molecular Biology and Translational Science
|June 24, 2018
PubMed
Summary

Early life adversity can program stress pathways, increasing adult mood disorder risk. Epigenetic changes from early experiences influence gene expression and long-term vulnerability to psychopathology.

Keywords:
early-life programmingenvironmental adversityepigenetic mechanismsmolecular mechanismsstress-regulating pathwaystherapeutic interventions

More Related Videos

Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life
07:17

Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life

Published on: February 2, 2017

13.8K
At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques
07:10

At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques

Published on: February 11, 2020

7.7K

Related Experiment Videos

Last Updated: Feb 8, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

11.3K
Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life
07:17

Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life

Published on: February 2, 2017

13.8K
At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques
07:10

At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques

Published on: February 11, 2020

7.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Biology

Background:

  • Early life adverse conditions are linked to increased risk of adult mood disorders.
  • Early-life programming hypothesis suggests environmental adversity shapes stress-regulating pathways, causing lasting changes in adult stress responsivity.
  • Gene-environment interactions are implicated in psychopathology development.

Purpose of the Study:

  • To review molecular mechanisms of early-life programming.
  • To examine the role of epigenetic mechanisms in translating early-life conditions into long-lasting gene expression changes.
  • To explore interactions between environments across developmental stages and transgenerational effects.

Main Methods:

  • Review of key findings from animal and clinical studies.
  • Examination of prenatal and postnatal environmental effects on neuroendocrine stress regulation.
  • Analysis of epigenetic mechanisms linking early experiences to gene expression and behavior.

Main Results:

  • Early-life adversity can lead to long-lasting alterations in stress responsivity.
  • Epigenetic mechanisms play a crucial role in mediating these programming effects.
  • Gene-environment interactions influence vulnerability to psychopathology.

Conclusions:

  • Understanding early-life programming and epigenetic marks is vital for molecular psychiatry.
  • This knowledge may inform new therapeutic interventions for mental disorders.
  • Prenatal and postnatal environments significantly impact long-term mental health vulnerability.