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Related Concept Videos

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
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Related Experiment Video

Updated: Feb 8, 2026

Methylated DNA Immunoprecipitation
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DNA Methylation and Psychiatric Disorders.

Chunyu Liu1, Chuan Jiao2, Kangli Wang2

  • 1University of Illinois, Chicago, IL, United States; School of Life Science, Central South University, Changsha, China.

Progress in Molecular Biology and Translational Science
|June 24, 2018
PubMed
Summary
This summary is machine-generated.

DNA methylation abnormalities are linked to psychiatric disorders. This review covers DNA methylation mechanisms, genetic/environmental factors, and findings in mental illness patients, exploring future treatment possibilities.

Keywords:
DNA methylationEWASepigenomicsgene expressionpathwaypsychiatric disorders

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • DNA methylation is crucial for gene regulation.
  • Aberrant DNA methylation patterns are implicated in the development of psychiatric disorders.
  • Understanding these epigenetic changes is key to unraveling mental illness etiology.

Purpose of the Study:

  • To review the mechanisms of DNA methylation.
  • To discuss the role of genetic and environmental factors in DNA methylation changes.
  • To summarize key findings on DNA methylation in psychiatric disorders.

Main Methods:

  • Literature review of studies on DNA methylation in psychiatric disorders.
  • Analysis of global and gene-specific methylation findings.
  • Discussion of current limitations and future directions in methylation research.

Main Results:

  • Evidence suggests a role for global and gene-specific DNA methylation abnormalities in psychiatric disorders.
  • Both genetic and environmental factors influence DNA methylation patterns relevant to mental illness.
  • Current research highlights the complexity of DNA methylation in the context of psychiatric conditions.

Conclusions:

  • DNA methylation is a significant area of study for understanding psychiatric disorders.
  • Improvements in data quality and analytical methods are needed.
  • DNA methylation-based therapies may offer future treatment avenues for mental illness.