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Lymphoma in autopsy cases.

Ahmad Alkhasawneh1, Aysha Mubeen2, Arun Gopinath2

  • 1Department of Pathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, 655 West 8th Street, Box C-506, Jacksonville, FL, 32209-6511, USA. Ahmad.alkhasawneh@jax.ufl.edu.

Forensic Science, Medicine, and Pathology
|June 24, 2018
PubMed
Summary

Autopsy can reveal unsuspected lymphoma, particularly in patients with vague symptoms. This study highlights how postmortem examinations identify missed lymphoma diagnoses, aiding understanding of lymphoproliferative disorders.

Keywords:
AutopsyImmunosuppressionLymphadenopathyLymphoma

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Area of Science:

  • Pathology
  • Oncology
  • Medical Diagnosis

Background:

  • Lymphoproliferative disorders, including lymphoma, contribute significantly to patient morbidity and mortality.
  • Clinical presentation of lymphoma can be vague, especially without lymphadenopathy, leading to diagnostic challenges.
  • Autopsy plays a crucial role in identifying missed diagnoses and understanding disease-related deaths.

Purpose of the Study:

  • To investigate the incidence and characteristics of clinically unsuspected lymphoma identified through autopsy.
  • To analyze the differences in presentation and cause of death between B-cell and T-cell lymphomas.

Main Methods:

  • Retrospective review of autopsy records over a 20-year period.
  • Identification of lymphoma cases, with a focus on those not diagnosed antemortem.
  • Correlation of clinical data with autopsy findings.

Main Results:

  • Fifteen cases of lymphoma were identified, with 5 diagnosed solely at autopsy.
  • B-cell lymphomas predominantly presented as nodal disease, while T-cell lymphomas showed widespread extranodal involvement.
  • Deaths in B-cell lymphoma were often linked to infection/immunosuppression from therapy, whereas T-cell lymphoma deaths resulted from organ infiltration.

Conclusions:

  • Autopsy is vital for diagnosing unsuspected lymphoma, especially in patients with nonspecific symptoms like skin rash or gastrointestinal issues.
  • Understanding the distinct patterns of B-cell and T-cell lymphomas aids in clinical suspicion and management.
  • Postmortem examination provides critical insights into the final stages and causes of death in lymphoproliferative disorders.