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Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
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EVLP: Ready for Prime Time?

Gabriel Loor1

  • 1Michael E. Debakey Department of Surgery, Baylor College of Medicine, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, Texas; Division of Cardiothoracic Transplantation and Circulatory Support, Texas Heart Institute, Houston, Texas.

Seminars in Thoracic and Cardiovascular Surgery
|June 24, 2018
PubMed
Summary
This summary is machine-generated.

Ex vivo lung perfusion keeps donor lungs viable outside the body. This review examines the XVIVO Perfusion System and Organ Care System, focusing on their clinical applications in lung transplantation.

Keywords:
End stage lung diseaseEx vivo lung perfusionLung transplantation

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Area of Science:

  • Thoracic surgery
  • Transplantation medicine
  • Medical device technology

Background:

  • Ex vivo lung perfusion (EVLP) enables lung assessment and reconditioning outside the body.
  • Current clinical trials feature two leading EVLP devices: the XVIVO Perfusion System (XPS) and the Organ Care System (OCS).

Purpose of the Study:

  • To review the clinical needs addressed by ex vivo lung perfusion.
  • To analyze the existing clinical literature for the XPS and OCS devices.

Main Methods:

  • Literature review of clinical studies on ex vivo lung perfusion devices.
  • Focus on the XVIVO Perfusion System and Organ Care System.

Main Results:

  • The review synthesizes data on the clinical utility of EVLP.
  • Comparative analysis of the XPS and OCS based on available literature.

Conclusions:

  • Ex vivo lung perfusion represents a significant advancement in lung transplantation.
  • Further clinical data is essential to fully understand the impact of XPS and OCS.