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Updated: Feb 8, 2026
07:46
Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
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[Bipolar disorders and anorexia nervosa: A clinical study].
M Valentin1, L Radon2, J Duclos3
1Centre hospitalier d'Argenteuil, 69, rue du Lieutenant-Colonel-Prudhon, 95100 Argenteuil, France.
L'Encephale
|June 25, 2018
Summary
Anorexia nervosa frequently co-occurs with bipolar disorders, especially in patients with a personal or family history. This comorbidity is linked to earlier onset, increased severity, and more psychiatric issues in anorexia nervosa patients.
Area of Science:
- Psychiatry
- Clinical Psychology
- Medical Research
Background:
- Anorexia nervosa (AN) often presents with mood disorders like depression.
- The role of bipolar disorder (BD) history in AN has been less explored.
- Understanding comorbidity is crucial for effective treatment.
Purpose of the Study:
- Assess the frequency of bipolar disorders in adolescent AN patients and their parents.
- Investigate if a history of bipolar disorder influences AN presentation, medical history, or treatment.
Main Methods:
- Evaluated 97 female patients (13-20 years) hospitalized for AN and their parents.
- Diagnoses of AN and BD were based on DSM-IV-TR criteria.
Main Results:
- Observed a high frequency of bipolar II and V disorders.
- AN patients with personal/family BD history showed earlier AN onset, more hospitalizations, and increased suicide attempts and comorbidities.
Conclusions:
- Anorexia nervosa and bipolar disorder comorbidity is significant.
- This comorbidity is associated with increased AN severity.
- The relationship between AN and BD warrants further investigation.
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