Related Experiment Video
Updated: Feb 8, 2026

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
Viscoelasticity Measurement in Rat Livers Using Shear-Wave US Elastography
Katsutoshi Sugimoto1, Fuminori Moriyasu2, Hisashi Oshiro3
1Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Abstract:
To investigate the usefulness of shear-wave speed and dispersion slope measurements obtained, using an ultrasound elastography system in rat livers with various degrees of necroinflammation and fibrosis. A total of 25 male Sprague Dawley rats were randomly divided into 5 groups of 5 rats each: G0 (control), G1 (CCl4 injected twice a week for 1 wk), G2 (CCl4 injected four times a wk for 1 wk), G3 (CCl4 injected twice a wk for 6 wk) and G4 (CCl4 injected twice a wk for 10 wk). The shear-wave speed (m/s) and the dispersion slope ([m/s]/kHz) were measured. Histologic features (inflammation, necrosis and fibrosis) were used as reference standards. In multivariable analysis with histologic features as independent variables, the fibrosis grade was significantly related to shear-wave speed (p < 0.05) and the necrosis grade was significantly related to dispersion slope (p < 0.05). Dispersion slope is more useful than shear-wave speed for predicting the degree of necroinflammation.
More Related Videos
05:56Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
07:57Viscoelastic Characterization of Soft Tissue-Mimicking Gelatin Phantoms using Indentation and Magnetic Resonance Elastography
Published on: May 10, 2022
Related Concept Videos
The Wave Nature of Light
Shear Diagram
First, a free-body diagram of the beam is drawn, representing all the external forces and internal reactions acting on the beam. One can calculate the reaction forces at each support by employing the equilibrium equations of force and moment. The vertical component...
Shearing Stress
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Shearing Strain
Normal and Shear Force
Singularity Functions for Shear