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Let thy food be thy medicine….when possible.

Renger F Witkamp1, Klaske van Norren1

  • 1Division of Human Nutrition and Health, Wageningen University, The Netherlands.

European Journal of Pharmacology
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Summary

Integrating nutrition and pharmacology offers new therapeutic avenues. This approach, aligning with ancient wisdom, targets complex diseases more effectively by combining lifestyle interventions with medicines, improving treatment outcomes.

Keywords:
Food-drug interactionsInflammationNutritionSarcopenia, Cachexia, Food-Pharma

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Area of Science:

  • Pharmacology and Nutritional Biology
  • Integrative Medicine
  • Chronic Disease Management

Background:

  • Reappraisal of the complementarity between nutrition and pharmacology, inspired by Hippocrates' philosophy.
  • Lifestyle interventions show therapeutic potential and offer insights into health-to-disease transitions.
  • Nutritional biology can identify novel molecular targets for disease intervention.

Purpose of the Study:

  • To review recent developments at the pharma-nutrition interface.
  • To discuss mechanisms, targets, and clinical examples of combined pharma-nutrition strategies.
  • To highlight the need for collaboration between pharmacology and nutrition.

Main Methods:

  • Review of recent scientific literature on the pharma-nutrition interface.
  • Analysis of molecular targets, receptors, and mechanisms.
  • Inclusion of clinical practice examples, including inflammatory diseases and muscle function loss.

Main Results:

  • Current drugs for cardio-metabolic diseases often target late-stage complications.
  • Multifactorial diseases benefit from multi-target approaches rather than single-drug strategies.
  • Combined nutrition and lifestyle interventions with medicines can enhance efficacy and reduce adverse effects.

Conclusions:

  • The pharma-nutrition interface demands intensified collaboration between disciplines.
  • Targeted combinations of medicines with nutrition and lifestyle interventions show promise.
  • Attention to potential negative food-drug interactions is crucial for safe and effective treatment.