Related Experiment Video
Updated: Feb 8, 2026
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Higher HbA1c and/or glucose levels alter the association patterns between glycated hemoglobin and fasting glucose
Lei Feng1, Shiyan Nian2, Yang Zhao3
1Department of Laboratory, People's Hospital of Yuxi City, 21 Nieer Road, Yuxi City, Yunnan Province 653100, PR China.
Insights
This study found that high hemoglobin A1c (HbA1c) and fasting glucose levels significantly alter the relationship between these markers and age in Chinese adults. These findings highlight the complex interplay of glucose control and demographic factors.
Area of Science:
- Endocrinology
- Metabolic Health
- Clinical Chemistry
Background:
- Hemoglobin A1c (HbA1c) and fasting glucose are key indicators of glycemic control.
- Understanding their correlation is crucial for diabetes management and risk assessment.
Purpose of the Study:
- To investigate the correlations between HbA1c and fasting glucose levels in a large Chinese population.
- To analyze how these correlations vary across different age groups and glycemic strata.
Main Methods:
- A cross-sectional study involving 14,249 Chinese subjects.
- Data analyzed in pooled, age-stratified, and HbA1c/fasting glucose-stratified populations.
- Pearson correlation coefficients (PCCs) and linear regression were employed.
Main Results:
- Strong positive correlations were observed between HbA1c and fasting glucose in pooled populations (PCCs ranging from 0.684 to 0.800).
- Significant correlations persisted within specific glycemic strata (e.g., HbA1c <6.5% and glucose <7.0 mmol/L, and HbA1c ≥6.5% and glucose ≥7.0 mmol/L).
- Fasting glucose and age were positively associated with HbA1c, while red blood cell count and red cell distribution width showed negative associations in lower glycemic groups.
Conclusions:
- High HbA1c and fasting glucose levels significantly modify the associations between these glycemic markers and age.
- The relationship between HbA1c, fasting glucose, and age is complex and influenced by the degree of glycemic control.
Aims:
To verify the correlations between HbA1c and fasting glucose levels.
Methods:
A cross-sectional study with 14,249 Chinese subjects. Objective was evaluated in pooled, age-stratified, HbA1c and fasting glucose-stratified populations.
Results:
In pooled populations, the Pearson correlation coefficients (PCCs) of males and females were 0.684 (P < 0.001) and 0.800 (P < 0.001), respectively. HbA1c and fasting glucose maintained significant correlations within the group with HbA1c < 6.5% and glucose <7.0 mmol/L and the group with HbA1c ≥ 6.5% and glucose ≥7.0 mmol/L in both males (PCC: 0.342, P < 0.001; and PCC: 0.765, P < 0.001, respectively) and females (PCC: 0.318, P < 0.001 and PCC: 0.788, P < 0.001, respectively). The slopes increased from the group with HbA1c < 6.5% and glucose <7.0 mmol/L to the group with HbA1c ≥ 6.5% and glucose ≥7.0 mmol/L in both males (0.26-0.44) and females (0.31-0.46). Linear regression analysis showed that fasting glucose and age were two common factors positively associated with HbA1C, and red blood cell count and red cell distribution width were two common factors negatively associated with HbA1c in both males and females with HbA1c < 6.5% and glucose <7.0 mmol/L. The correlations changed dramatically in the groups with HbA1c ≥ 6.5% and glucose <7.0 mmol/L and HbA1c < 6.5% and glucose ≥7.0 mmol/L.
Conclusions:
High HbA1c and fasting glucose levels greatly altered the associations between HbA1c, glucose and age.
More Related Videos
04:54Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
Published on: June 2, 2023
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Related Concept Videos
01:02Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
01:27Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
01:29Leveling Effect
01:19High-Level and Low-Level Awareness
01:26Glucose Absorption Into the Small Intestine
01:16Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...