Related Experiment Video For EMT
Updated: Feb 8, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop
Neda Alidadiani1, Shahrooz Ghaderi1, Nafi Dilaver2
1Department of system physiology, Rhur University Bochum, Bochum, Germany.
Abstract:
Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a variety of factors such as transcription factors (TFs), coding genes and microRNAs (miRs). Both TFs and miRs are trans-regulatory elements that crosstalk. Due to a wide range of targets, TF-miR interaction provides a feedback or feedforward loop and cross-gene regulation consequently. In this review, we focused on the structure and function of two TF families involved in EMT, zinc finger and β helix loop helix and p53. Subsequently we analyzed recent findings on TF-miR interaction in EMT.
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