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Related Experiment Video

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Development of murine bariatric surgery models: lessons learned.

Heather A Frohman1, Piotr G Rychahou1, Jing Li2

  • 1Department of Surgery, University of Kentucky, Lexington, Kentucky; Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

The Journal of Surgical Research
|June 26, 2018
PubMed
Summary

Researchers developed a reproducible mouse model for Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric surgeries. This model aims to advance understanding of the physiological and genetic impacts of these life-changing procedures.

Keywords:
Bariatric surgeryMurine modelRoux-en-Y gastric bypass

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Area of Science:

  • Bariatric Surgery Research
  • Surgical Innovation
  • Murine Models

Background:

  • Bariatric surgery, including Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), effectively treats obesity comorbidities like diabetes and hypertension.
  • A reliable murine model is crucial for investigating the physiological and genetic mechanisms underlying bariatric surgery's benefits, especially for genetically engineered mouse studies.
  • Implementing complex bariatric procedures in small rodents has been technically challenging, limiting research.

Purpose of the Study:

  • To establish a technically feasible and reproducible murine model for both RYGB and SG procedures.
  • To provide a foundation for future studies on the physiological and genetic influences of bariatric surgery using genetically modified mice.

Main Methods:

  • Mice were transitioned to a liquid diet perioperatively without fasting and housed in groups on raised wire platforms.
  • Sleeve gastrectomy (SG) involved stomach volume reduction with multilayer gastrotomy repair.
  • Roux-en-Y gastric bypass (RYGB) included side-to-side and functional end-to-side bowel anastomoses with gastric exclusion.

Main Results:

  • Postoperative survival rates at 1 month were 100% for SG and 41% for RYGB.
  • RYGB mortality was primarily attributed to physiological stress, dumping, or malnutrition rather than surgical complications like leaks or strictures (26%).
  • Perioperative husbandry and management were identified as key challenges impacting survival in this small rodent model.

Conclusions:

  • The described perioperative and surgical techniques enhance the feasibility and survival rates for technically demanding murine bariatric surgery models.
  • This reproducible murine model will facilitate deeper investigation into the mechanisms behind the beneficial effects of bariatric surgery.
  • Further refinement of perioperative care is essential for optimizing survival in murine models undergoing complex bariatric procedures.