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As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Related Experiment Video

Updated: Feb 8, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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Pathogenomics of Endometriosis Development.

Vladislav Baranov1, Olga Malysheva2, Maria Yarmolinskaya3

  • 1D.O.Ott Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg 199034, Russia. baranov@vb2475.spb.edu.

International Journal of Molecular Sciences
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

Endometriosis research reveals a genetic program influencing stem cell origins and progression to disease. This discovery may lead to new prediction, prevention, and treatment strategies for this chronic condition.

Keywords:
developmental pathwayendometriosismesenchymal stem cellspathogenomics

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Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
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Area of Science:

  • Reproductive medicine
  • Genetics
  • Molecular biology

Background:

  • Endometriosis is a chronic, estrogen-dependent disease affecting 5-10% of women of reproductive age.
  • Despite extensive research, its pathophysiology and pathogenomics remain poorly understood.
  • New technologies offer insights into molecular mechanisms involving stem cells.

Purpose of the Study:

  • To outline novel molecular, genetic, and epigenetic mechanisms in endometriosis development.
  • To hypothesize an endometriosis development genetic program (EMDP).
  • To discuss the significance of EMDP for future endometriosis management.

Main Methods:

  • Review of recent molecular, genetic, and epigenetic studies.
  • Hypothetical model of endometriosis development via EMDP.
  • Discussion of a unifying theory for endometriosis.

Main Results:

  • Proposes an EMDP governing stem cell origin, metaplasia, and lesion progression.
  • Highlights complex genomic and epigenetic interactions in disease development.
  • Identifies distinct disease forms based on molecular profiles.

Conclusions:

  • The hypothesized EMDP provides a framework for understanding endometriosis pathogenesis.
  • EMDP offers potential for novel prediction, prevention, and treatment strategies.
  • Further research into EMDP is crucial for advancing endometriosis care.