Related Experiment Video
Updated: Feb 8, 2026
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
Role of T-Helper 9 Cells in Chronic Hepatitis C-Infected Patients
Mohamed E Ali1, Omnia El-Badawy2, Noha A Afifi3
1Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. elkady4work@azhar.edu.eg.
Insights
T-helper 9 cells increase with hepatitis C virus (HCV) pathogenesis and decrease during viral clearance. This suggests T-helper 9 cells are key to HCV progression and related complications.
Area of Science:
- Immunology
- Virology
- Hepatology
Background:
- Hepatitis C virus (HCV) infection involves immune cell modulation, impacting viral spread and complications.
- T-helper 9 cells are implicated in various immunopathological conditions, with debated roles in viral infections.
Purpose of the Study:
- To investigate the role of T-helper 9 cells in the pathogenesis of Hepatitis C virus (HCV).
- To determine the association between T-helper 9 cell levels and HCV progression and clearance.
Main Methods:
- Monitoring T-helper 9 cell populations and receptor expression in HCV patients.
- Correlating T-helper 9 cell dynamics with viral load and disease progression.
Main Results:
- T-helper 9 cell numbers significantly increase with advancing HCV pathogenesis.
- Viral clearance in HCV patients is associated with a reduction in T-helper 9 cells.
- Increased T-helper 9 cell levels correlate with elevated receptor expression.
Conclusions:
- T-helper 9 cells play a significant role in the pathogenesis of Hepatitis C virus.
- The dynamic changes in T-helper 9 cells are directly linked to HCV progression and associated complications.
Abstract:
Hepatitis C virus is a hepatotropic virus that is transmitted parenterally. Viral infections are usually associated with modulations of the immune cells, leading to enhanced viral survival and spreading, and accordingly, life-threatening complications. Recently, it has been proposed that a new subset of T-helper, named T-helper 9, is involved in the pathogenesis of different immunopathological conditions, such as allergies, tumors, and viral infections. Some studies reported a protective role, and others described a pathogenic potential for the T-helper 9 cells. Here, we present evidence that T-helper 9 cells are dynamically increased with increasing the pathogenic strategy for hepatitis C virus (HCV). Furthermore, viral clearance is associated with a decrease in T-helper 9. The increase in T-helper 9 was paralleled with an increase in its receptor expression. Taken together, our data suggest that T-helper 9 cells play an important role in the pathogenesis of HCV, and is directly associated with HCV-related complications.
Related Concept Videos
01:14Hepatic Drug Clearance: Role of Transporters
01:18Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
01:02Role of Microtubules in Cell Wall Deposition
01:10The Role of Actin and Myosin in Non-muscle Cells
01:21Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...