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HLA-DRB1 gene polymorphisms in Iranian children with Henoch-Schönlein purpura

Saadyeh Rashidi1, Reza Shiari2, Shirin Farivar1

  • 1Department of Biology, Faculty of Biological Sciences and Technology, Shahid Beheshti University, Tehran, Iran.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|June 26, 2018
PubMed

Insights

This study found that specific human leukocyte antigen (HLA) gene variations, HLA-DRB1*01 and HLA-DRB1*11, are associated with Henoch-Schönlein purpura (HSP) in Iranian children, suggesting a genetic link to the condition.

Area of Science:

  • Immunogenetics
  • Pediatric Vasculitis

Background:

  • Henoch-Schönlein purpura (HSP) is the most common childhood vasculitis.
  • The human leukocyte antigen (HLA) region on chromosome 6p21.3 is implicated in HSP pathogenesis.
  • HLA-DRB1 alleles are suspected due to high polymorphism and potential association with HSP.

Purpose of the Study:

  • To investigate the association between HLA-DRB1 alleles and Henoch-Schönlein purpura (HSP) in Iranian children.
  • To identify specific HLA-DRB1 genetic markers linked to HSP susceptibility in this population.

Main Methods:

  • A case-control study involving 30 Iranian children with HSP and 35 healthy controls.
  • Genomic DNA extraction and human leukocyte antigen (HLA) typing using polymerase chain reaction with sequence-specific primers (PCR-SSP).

Main Results:

  • HLA-DRB1*01 and HLA-DRB1*11 alleles showed a significant association with HSP in Iranian children (P=0.002, OR=7.579; P=0.039, OR=3.333, respectively).
  • No significant difference in other HLA-DRB1 allele frequencies was observed between cases and controls.
  • No correlation was found between HLA types and clinical manifestations of HSP.

Conclusions:

  • The study concludes a significant association between HLA-DRB1*01 and HLA-DRB1*11 gene polymorphisms and susceptibility to Henoch-Schönlein purpura (HSP) in the studied Iranian children.
  • These findings highlight the role of specific HLA-DRB1 alleles in the genetic predisposition to HSP.
Abstract

Keywords:
Autoimmune diseaseHLA-DRB1Henoch-Schönlein purpurapolymorphismvasculitis

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