Related Experiment Video
Updated: Feb 8, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds
Published on: June 6, 2015
Anti-cancer binary system activated by bacteriophage HK022 integrase
Amer Elias1, Natasha Gritsenko1, Rena Gorovits2
1Department of Biochemistry and Molecular Biology, Tel-Aviv University, Tel-Aviv 69978, Israel.
Abstract:
The binary system presented in this work is based on the bacteriophage HK022 integrase recombinase that activates the expression of a silenced Diphtheria toxin gene, both controlled by the cancer specific hTERT promoter. Using a lung cancer mice model, assays of different apoptotic and anti-apoptotic factors have demonstrated that the Integrase based binary system is highly specific towards cancer cells and more efficient compared to the conventional mono system whose toxin is directly expressed under hTERT. In a mice survival test, this binary system demonstrated longer persistence compared to the untreated and the mono treated ones. The reason underlying the advantage of this binary system over the mono system seems to be an overexpression of various hTERT suppressing factors induced by the mono system.
Related Concept Videos
Lysogenic Cycle of Bacteriophages
Lytic Cycle of Bacteriophages
Binary Fission
Binary Fission
DNA Bacteriophages
Waterproofing and Anti-Bacterial Admixtures in Concrete
Waterproofing admixtures render concrete hydrophobic,...

