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Related Experiment Video

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Trojan-Horse-Like Stimuli-Responsive Microcapsules.

Chuan-Lin Mou1,2, Wei Wang1,3, Zhi-Lu Li1

  • 1School of Chemical Engineering Sichuan University Chengdu Sichuan 610065 China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed Trojan-horse-like microcapsules using microfluidics for controlled release. These microcapsules enable flexible, programmed sequential release of different contents from nested compartments, advancing microcarrier technology.

Keywords:
Trojan‐horse‐like microcapsulesinterfacesmicrofluidicsprogrammed releasestimuli‐responsive materials

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Nanotechnology

Background:

  • Multicompartment microcapsules are crucial for advanced microcarriers, enabling controlled release of encapsulated substances.
  • Existing microcapsules often lack the ability to combine diverse release mechanisms for sequential, programmed delivery.
  • Stimuli-responsive shells are key for controlling release, but integrating multiple distinct responses remains challenging.

Purpose of the Study:

  • To develop a novel method for synthesizing stimuli-responsive microcapsules with distinct, independently controllable release mechanisms.
  • To create microcapsules capable of programmed sequential release of different payloads from nested compartments.
  • To demonstrate the versatility of these microcapsules for diverse applications requiring tailored release profiles.

Main Methods:

  • One-step template synthesis of Trojan-horse-like microcapsules using microfluidic quadruple emulsions.
  • Fabrication of capsule-in-capsule structures with nested inner and outer compartments.
  • Utilizing distinct stimuli-responsive hydrogel shells for independent control over each compartment's release.

Main Results:

  • Successfully synthesized controllable Trojan-horse-like stimuli-responsive microcapsules with capsule-in-capsule architecture.
  • Demonstrated independent control over content release from both inner and outer compartments via distinct stimuli-responsive shells.
  • Showcased flexible programmed sequential release using three types of microcapsules with varied release combinations.

Conclusions:

  • The developed microcapsules offer a versatile platform for programmed sequential release, overcoming limitations of current multicompartment systems.
  • These microcapsules represent advanced candidates for next-generation microcarriers with enhanced efficiency and diverse application potential.
  • The microfluidic approach provides a scalable and controllable method for fabricating complex microcapsule structures.