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An In Vitro Approach to Photodynamic Therapy
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An In Vitro Approach to Photodynamic Therapy

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Using X-rays in photodynamic therapy: an overview.

L Larue1, A Ben Mihoub2, Z Youssef1

  • 1Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, Université de Lorraine, CNRS, Nancy, France. celine.frochot@univ-lorraine.fr.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) offers cancer treatment options. A new approach, PDTX, uses X-rays for deeper tissue penetration, enhancing PDT efficacy for challenging tumors.

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Area of Science:

  • Oncology
  • Biophysics
  • Medical Physics

Background:

  • Photodynamic therapy (PDT) is an established treatment for various diseases, including cancers.
  • Current PDT limitations include poor light penetration in deep tissues.
  • Strategies like targeted photosensitizers (PS) and advanced light dosimetry are being developed to enhance PDT efficacy.

Purpose of the Study:

  • To review the emerging field of X-ray-based photodynamic therapy (PDTX).
  • To discuss the principles and current literature of PDTX.
  • To explore photosensitizers and nanoparticles for PDTX applications.

Main Methods:

  • Literature review of PDTX principles and applications.
  • Discussion of photosensitizers suitable for X-ray excitation.
  • Analysis of nanoparticles designed for X-ray to UV-visible light conversion.

Main Results:

  • PDTX utilizes X-rays for enhanced light penetration, overcoming a key PDT limitation.
  • Various photosensitizers have been investigated for use with X-ray irradiation.
  • Nanoparticles capable of converting ionizing radiation to UV-visible light show promise for PDTX.

Conclusions:

  • PDTX represents a novel approach to improve the efficacy of photodynamic therapy for deep-seated tumors.
  • Further research into photosensitizers and specialized nanoparticles is crucial for advancing PDTX.
  • This modality holds potential for treating challenging cancers like glioblastoma and mesothelioma.