PET imaging for assessing tumor response to therapy.
David A Mankoff1, Sharyn I Katz1
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Journal of Surgical Oncology
|June 26, 2018
Summary
Positron emission tomography (PET) provides quantitative imaging of molecular probes to measure cancer therapy-induced biochemical changes. This review covers PET principles, radiopharmaceuticals, tumor analysis, and applications for assessing cancer treatment response.
Area of Science:
- Nuclear medicine
- Molecular imaging
- Oncology
Background:
- Positron emission tomography (PET) is a powerful radioisotope imaging technique.
- PET enables quantification of molecular imaging probes targeting specific biochemical pathways.
- It allows direct measurement of biochemical changes during cancer therapy.
Purpose of the Study:
- To review the fundamental principles of PET imaging.
- To discuss the selection of PET radiopharmaceuticals for cancer research.
- To explore PET applications in assessing cancer therapy response and future directions.
Main Methods:
- Review of established PET imaging principles.
- Analysis of radiopharmaceutical selection criteria.
- Examination of tumor analysis methodologies.
- Compilation of current PET applications in cancer therapy assessment.
Main Results:
- PET offers quantitative insights into molecular targets and cellular populations.
- It can directly measure treatment-induced biochemical pathway activity.
- PET facilitates the assessment of targeted therapy efficacy.
Conclusions:
- PET is a valuable tool for monitoring cancer therapy response.
- Understanding PET principles and radiopharmaceuticals is crucial for its application.
- Future directions include advanced analysis and novel probe development for improved cancer management.
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