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Updated: Feb 8, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Thirty Years of (TMS)3SiH: A Milestone in Radical-Based Synthetic Chemistry
Chryssostomos Chatgilialoglu1, Carla Ferreri1, Yannick Landais2
1ISOF, Consiglio Nazionale delle Ricerche , Via P. Gobetti 101 , 40129 Bologna , Italy.
Abstract:
This review is an update on tris(trimethylsilyl)silane, TTMSS, in organic chemistry, focusing on the advancements of the past decade. The overview includes a wide range of chemical processes and synthetic strategies under different experimental conditions, including functional group insertion and transformations, as well as preparation of complex molecules, natural products, polymers, surfaces, and new materials. These results reveal how TTMSS has matured over the past 30 years, and they further establish its value as a free radical reagent with widespread academic and industrial applications.
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