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Biological therapies for eosinophilic asthma
Shiven S Patel1, Thomas B Casale1, Juan Carlos Cardet1
1a Division of Allergy and Immunology, Department of Internal Medicine , University of South Florida Morsani College of Medicine and James A. Haley Veterans' Affairs Hospital , Tampa , FL , USA.
Expert Opinion on Biological Therapy
|June 26, 2018
Summary
New biologic therapies targeting specific pathways offer effective treatment options for severe uncontrolled asthma, particularly eosinophilic asthma, improving outcomes when traditional methods fail.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Severe uncontrolled asthma is often refractory to conventional treatments.
- Identifying distinct asthma phenotypes is crucial for effective management.
- Traditional therapies may have intolerable side effects or limited efficacy.
Purpose of the Study:
- To review the development and clinical trial data of biologic therapies for severe asthma.
- To highlight the benefits of biologics in patients with severe eosinophilic asthma.
- To discuss the role of targeted therapies in managing distinct asthma phenotypes.
Main Methods:
- Review of clinical trials for monoclonal antibodies targeting IL-5/IL-5Rα, IgE, and IL-4Rα.
- Analysis of treatment outcomes, including asthma exacerbations and clinical endpoints.
- Evaluation of safety profiles and pharmacoeconomic considerations.
Main Results:
- Biologic therapies targeting IL-5, IgE, and IL-4/IL-13 pathways show favorable results in severe eosinophilic asthma.
- These agents reduce asthma exacerbations and improve other clinical outcomes.
- Some biologics demonstrate efficacy irrespective of peripheral eosinophil counts.
Conclusions:
- Monoclonal antibodies offer valuable treatment alternatives for severe uncontrolled asthma.
- Targeted biologic therapies are particularly beneficial for patients with severe eosinophilic asthma.
- Careful patient selection is advised due to high costs and limited long-term safety data.
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