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Bioinspired Mineral-Organic Bioresorbable Bone Adhesive
Alina Kirillova1, Cambre Kelly1, Natalia von Windheim1
1Department of Mechanical Engineering and Materials Science, Edmund T. Pratt Jr., School of Engineering, Duke University, Durham, NC, 27708, USA.
Advanced Healthcare Materials
|June 26, 2018
Summary
A novel bioresorbable bone adhesive, inspired by marine organisms, offers strong bone bonding and integrates with implants. This breakthrough material shows promise for revolutionizing skeletal repair without permanent hardware.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Regenerative Medicine
Background:
- Bioresorbable bone adhesives are needed for skeletal repair, but current options lack sufficient bone adhesion, osteointegration, and bioresorbability.
- Existing clinical bone cements, like calcium phosphate cement and poly(methyl methacrylate), have limitations in strength and bioresorbability.
Purpose of the Study:
- To develop and evaluate a novel bioresorbable bone adhesive with high adhesive strength, osteointegration, and bioresorbability.
- To assess the adhesive's performance compared to current clinical standards and its compatibility with metallic implants.
Main Methods:
- A novel bone adhesive was formulated using tetracalcium phosphate and phosphoserine.
- The adhesive's curing time, bone-to-bone adhesive strength, and adhesion to titanium were measured.
- Osteointegration and bioresorbability were assessed in a rabbit distal femur defect model over 52 weeks.
Main Results:
- The novel adhesive cures in minutes in an aqueous environment.
- It demonstrated 10 times greater bone-to-bone adhesion than bioresorbable calcium phosphate cement and 7.5 times greater than poly(methyl methacrylate) bone cement.
- Adhesion to titanium was twice that of adhesion to bone, and the material showed successful osteointegration and bioresorbability in vivo.
Conclusions:
- This novel tetracalcium phosphate and phosphoserine-based bone adhesive exhibits superior adhesive strength and bioresorbability compared to current standards.
- Its ability to bond bone effectively and adhere to titanium implants opens new possibilities for orthopedic applications.
- The material demonstrates significant potential for revolutionizing bone fixation and healing without the need for permanent hardware.
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