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[A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention

Jiaxiu Zhou1, Yingxue Gao2, Xuan Bu2

  • 1Department of Psychology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|June 26, 2018
PubMed

Insights

Children with attention-deficit/hyperactivity disorder (ADHD) show reduced brain activity in frontal and occipital regions. These differences in spontaneous neural activity correlate with cognitive and anxiety measures.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Radiology

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is associated with functional brain abnormalities.
  • Conflicting results exist, and few studies examine homotopic functional connectivity.
  • Understanding intrinsic brain activity in ADHD is crucial.

Purpose of the Study:

  • To investigate intrinsic brain activity differences between medication-naïve children with ADHD and healthy controls.
  • To analyze regional homogeneity (ReHo), degree centrality (DC), and voxel-mirrored homotopic connectivity (VMHC).
  • To explore correlations between brain activity and clinical measures.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data from 45 ADHD children and 26 controls.
  • Comparison of ReHo, DC, and VMHC values between groups.
  • Correlation analysis with Conners' Parent Rating Scale (CPRS-R) and Wisconsin Card Sorting Test (WCST).

Main Results:

  • ADHD children had significantly lower ReHo and DC in the right middle frontal gyrus.
  • Lower VMHC was observed in the bilateral occipital lobes of ADHD children.
  • Lower VMHC correlated negatively with anxiety and positively with WCST performance.

Conclusions:

  • ADHD is associated with reduced spontaneous neuronal activity in the right middle frontal gyrus.
  • Impaired homotopic connectivity in bilateral occipital lobes is linked to ADHD.
  • These findings highlight distinct patterns of intrinsic brain activity in ADHD.

Keywords:
attention-deficit/hyperactivity disorderdegree centralityfunctional magnetic resonance imagingregional homogeneityvoxel-mirrored homotopic connectivity

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