Cancer Metabolism: Current Understanding and Therapies

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Jessica L Counihan1, Elizabeth A Grossman1, Daniel K Nomura1

  • 1Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology , University of California, Berkeley , Berkeley , California 94720 , United States.

Chemical Reviews
|June 26, 2018
PubMed

Insights

Cancer cell metabolism dysregulation fuels abnormal growth. This review covers oncogenes, metabolic pathways, and targeted therapies addressing these cancer abnormalities.

Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Research

Background:

  • Cancer cell metabolism is fundamentally altered, supporting uncontrolled proliferation.
  • Specific oncogenes and metabolic pathways are frequently implicated in cancer development and progression.

Purpose of the Study:

  • To review key oncogenes and metabolic pathways involved in cancer.
  • To discuss how these metabolic changes drive cancer pathogenesis.
  • To explore pharmacological strategies and targeted therapies for cancer metabolism.

Main Methods:

  • Literature review of oncogenes and metabolic pathways in cancer.
  • Analysis of the contribution of metabolic dysregulation to cancer malignancy.
  • Examination of current targeted therapies based on metabolic vulnerabilities.

Main Results:

  • Identified numerous oncogenes and metabolic pathways critical to cancer.
  • Detailed how metabolic alterations promote cancer pathogenesis and malignancy.
  • Highlighted the development of targeted therapies exploiting metabolic dependencies.

Conclusions:

  • Targeting cancer cell metabolism offers promising therapeutic strategies.
  • Understanding metabolic reprogramming is key to developing novel cancer treatments.
  • Pharmacological interventions against cancer metabolism are advancing rapidly.

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