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Related Experiment Videos

Functional Mitral Regurgitation: An Interventional Cardiologist's Perspective.

Lowie M R Van Assche1, Mark J Ricciardi

  • 1From the Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Cardiology in Review
|June 26, 2018
PubMed
Summary

Functional mitral regurgitation (FMR) affects heart failure patients, worsening prognosis. This review covers FMR causes, current treatments, and emerging transcatheter mitral valve repair and replacement devices.

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Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • Functional mitral regurgitation (FMR) is a prevalent complication in heart failure patients.
  • FMR is associated with adverse cardiac remodeling and a poor clinical prognosis.
  • Current treatments include medical therapy, cardiac resynchronization, and surgical interventions.

Purpose of the Study:

  • To review the pathophysiology, classification, and prognosis of FMR.
  • To provide an overview of existing and emerging therapeutic strategies for FMR.
  • To examine the current evidence and future directions for transcatheter mitral valve interventions in FMR.

Main Methods:

  • Literature review of pathophysiology, clinical trials, and device development for FMR.

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  • Analysis of current guideline-directed medical therapy and device-based interventions.
  • Discussion of transcatheter mitral valve repair (e.g., MitraClip) and replacement devices.

    • Main Results:

    • FMR stems from adverse remodeling in ischemic or nonischemic heart failure.
    • Transcatheter mitral valve repair (MitraClip) is under investigation for FMR.
    • Several transcatheter mitral valve replacement devices are also being developed for FMR.

    Conclusions:

    • FMR significantly impacts heart failure outcomes, necessitating effective treatment strategies.
    • Transcatheter interventions offer promising alternatives for FMR management.
    • Ongoing clinical trials and device innovation are crucial for advancing FMR treatment.