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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

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ACOG Practice Bulletin No. 197 Summary: Inherited Thrombophilias in Pregnancy

    Obstetrics and Gynecology
    |June 26, 2018
    PubMed

    Insights

    Inherited thrombophilias increase venous thromboembolism risk in pregnancy. This revised guidance reviews screening, management, and prophylaxis for these conditions during pregnancy and postpartum.

    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Reproductive Medicine

    Background:

    • Inherited thrombophilias are genetic conditions increasing the risk of blood clots.
    • These conditions are linked to adverse pregnancy outcomes and venous thromboembolism (VTE).
    • Current evidence guiding screening and management of thrombophilia in pregnancy is limited.

    Purpose of the Study:

    • To review common inherited thrombophilias and their association with maternal VTE risk.
    • To discuss adverse pregnancy outcomes linked to thrombophilia.
    • To provide updated guidance on screening indications and management options during pregnancy.

    Main Methods:

    • Literature review of inherited thrombophilias and pregnancy outcomes.
    • Analysis of current evidence on screening and management strategies.
    • Incorporation of updated consensus guidelines on thromboprophylaxis.

    Main Results:

    • Inherited thrombophilias significantly elevate the risk of VTE in pregnant individuals.
    • Specific thrombophilias are associated with increased rates of adverse pregnancy outcomes.
    • Updated guidelines address prophylaxis needs during pregnancy and postpartum periods.

    Conclusions:

    • Screening and management of inherited thrombophilias in pregnancy require careful consideration.
    • Prophylaxis decisions should be individualized based on risk assessment.
    • New guidelines offer critical insights for obstetric anesthesia and perinatology regarding thromboprophylaxis.

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