Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

341
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
341
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

548
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
548
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

371
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
371
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

332
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
332
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

516
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
516
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

585
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
585

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loneliness, Anxiety Symptoms, Depressive Symptoms, and Suicidal Ideation in the All of Us Dataset.

JAMA network open·2026
Same author

Clinical Note-Extracted Psychosocial Factors for Predicting Suicide Attempt Among ED Patients With Suicidal Ideation.

JAMA network open·2026
Same author

Trends in unintentional injury death among post-9/11 Army Veterans who do and do not use Veteran Health Administration services.

Injury epidemiology·2026
Same author

A Treatment Selection Model for Opioid Use Disorder Using Electronic Health Record and ZIP-Level Data.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Prospective Validation of a Suicide Event Risk Model in Transgender Patients.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Identifying and supporting trafficked individuals: provider and community organization perspectives on existing sociotechnical approaches.

Journal of the American Medical Informatics Association : JAMIA·2025
Same journal

Evaluation of temporal preservation in synthetic longitudinal patient data.

Journal of biomedical informatics·2026
Same journal

ARKE: An ontology-driven framework for automated mapping of local radiology procedure terms to the LOINC-RadLex playbook using large language model.

Journal of biomedical informatics·2026
Same journal

A validation-driven training controller for cross-lingual biomedical NER via reinforcement learning-based adaptive loss weighting.

Journal of biomedical informatics·2026
Same journal

ASP-HR: An Adaptive Spatial Perception and Hierarchical Reasoning mechanism for document-level biomedical relation extraction.

Journal of biomedical informatics·2026
Same journal

Beyond Accuracy: Safety-Centered guidelines for the evaluation of LLM-based therapy recommendation systems for chronic multimorbidity patients.

Journal of biomedical informatics·2026
Same journal

DeepEN: A deep reinforcement learning framework for personalized enteral nutrition in critical care.

Journal of biomedical informatics·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.6K

Discovering hidden knowledge through auditing clinical diagnostic knowledge bases.

Matthew C Lenert1, Colin G Walsh2, Randolph A Miller2

  • 1Dept. of Biomedical Informatics, Vanderbilt University, 2525 West End Ave. Suite 1475, Nashville, TN 37203, USA.

Journal of Biomedical Informatics
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

Data mining techniques can efficiently identify hidden relationships in diagnostic knowledge bases. This improves completeness for applications like differential diagnosis, with heuristic algorithms showing significant efficiency gains.

Keywords:
Data auditingInternal medicineKnowledge bases

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.2K
Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task
06:08

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task

Published on: July 22, 2025

958

Related Experiment Videos

Last Updated: Feb 8, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.6K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.2K
Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task
06:08

Exploring the Role of Deontic Reasoning and World Knowledge in Wason´s Selection Task

Published on: July 22, 2025

958

Area of Science:

  • Medical Informatics
  • Knowledge Representation
  • Data Mining

Background:

  • Diagnostic knowledge bases (KB) are crucial for clinical decision support.
  • Ensuring the completeness of relationships within KBs is essential for accurate applications.
  • Current methods for KB maintenance can be labor-intensive.

Purpose of the Study:

  • To evaluate data mining techniques for identifying hidden concepts in diagnostic KBs.
  • To assess the potential for improving KB completeness and application performance.
  • To estimate the efficiency gains from using data mining for KB auditing.

Main Methods:

  • Applied unsupervised learning methods: Pearson's correlation (PC), Kendall's correlation (KC), and a heuristic algorithm (HA).
  • Utilized the INTERNIST-1/QMR KB to identify existing and discover new finding-finding interrelationships ('properties').
  • Estimated the efficiency and effort reduction associated with these data mining approaches.

Main Results:

  • Discovered new properties with varying confidence intervals: PC [0.1%, 5.4%], KC [2.8%, 12.5%], and HA [5.6%, 18.8%].
  • The heuristic algorithm (HA) demonstrated the highest rate of new property discovery.
  • Estimated a 50-fold reduction in manual effort for identifying new properties using the HA approach.

Conclusions:

  • Data mining offers an efficient method to supplement the completeness of diagnostic KBs.
  • The findings are applicable to other diagnostic systems utilizing finding frequencies, such as DXplain and ISABEL.
  • Automated auditing via data mining can enhance the maintenance and utility of medical knowledge bases.