Related Experiment Video
Updated: Feb 8, 2026
10:26
Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
Published on: November 7, 2019
6.1K
The immunobiology of ubiquitin-dependent B cell receptor functions
1Albany Medical College, Department of Immunology and Microbial Disease, 47 New Scotland Ave., MC-151, Albany, NY 12208-3479, United States.
Molecular Immunology
|June 26, 2018
Summary
B cells process and present antigens via their B cell receptor (BCR), a crucial step for T cell activation and tolerance. This review details BCR-mediated antigen processing, focusing on ubiquitination
Area of Science:
- Immunology
- Cell Biology
Background:
- MHC class II antigen presentation is vital for T cell responses.
- B cells, dendritic cells, and macrophages present antigens via MHC class II.
- B cells uniquely express high MHC class II and antigen-specific B cell receptors (BCR).
Purpose of the Study:
- To review the processing and presentation of BCR-bound antigens by B cells.
- To highlight the role of BCR ubiquitination in antigen processing.
- To discuss the implications for B cell and T cell interactions.
Main Methods:
- Review of existing literature on BCR-mediated antigen processing.
- Focus on endocytosis, intracellular trafficking, and peptide-MHC class II complex generation.
- Emphasis on the role of ubiquitination in these processes.
Main Results:
- BCR-mediated antigen processing involves endocytosis, trafficking, and peptide generation.
- Ubiquitination of the BCR plays a significant role in these steps.
- This process impacts T cell activation, regulation, and tolerance.
Conclusions:
- BCR-mediated antigen processing is a complex, multi-step pathway.
- Ubiquitination is a key regulatory mechanism in BCR antigen presentation.
- Understanding this pathway is critical for B cell immunology and therapeutic strategies.
Related Concept Videos
01:28Types of Receptors: Cell Surface Receptors
27.5K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.5K
01:31Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
01:21Frequency-dependent Selection
24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
01:39Receptor-mediated Endocytosis
111.1K
Overview
111.1K
01:19Contact-dependent Signaling
47.6K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
47.6K
01:17Drug Dependence
1.7K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.7K