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Related Concept Videos

Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
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Lewis Acids and Bases02:16

Lewis Acids and Bases

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This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
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Ions as Acids and Bases02:54

Ions as Acids and Bases

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Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

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An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
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Bronsted-Lowry Acids and Bases02:58

Bronsted-Lowry Acids and Bases

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The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
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Acid-Base Titration Curves02:23

Acid-Base Titration Curves

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A titration curve is a plot of some solution property versus the amount of added titrant. For acid-base titrations, solution pH is a useful property to monitor because it varies predictably with the solution composition and, therefore, may be used to monitor the titration’s progress and detect its endpoint. Acid-base titration can be performed with a strong acid and a strong base, a strong acid and a weak base, or a strong base and a weak acid.
For a titration carried out for 25.00 mL of...
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Elastomeric PGS Scaffolds in Arterial Tissue Engineering
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Hyaluronic acid-based scaffolds for tissue engineering.

Cristina Chircov1, Alexandru Mihai Grumezescu, Ludovic Everard Bejenaru

  • 1Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; grumezescu@yahoo.com.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|June 26, 2018
PubMed
Summary

Hyaluronic acid (HA) scaffolds are vital for tissue engineering due to their biocompatibility and biodegradability. This review explores various HA-based scaffold forms like hydrogels and sponges for regenerative medicine applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Hyaluronic acid (HA) is a natural glycosaminoglycan in connective tissue extracellular matrix.
  • HA is a hydrophilic polymer with a rapid degradation rate.
  • Its biocompatibility, biodegradability, and modifiability make it suitable for tissue engineering.

Purpose of the Study:

  • To review the current state of HA-based scaffolds for tissue engineering.
  • To discuss various processing techniques and resulting scaffold forms.
  • To highlight the potential of HA in regenerative medicine.

Main Methods:

  • Literature review of HA-based scaffold fabrication and applications.
  • Analysis of different scaffold morphologies (hydrogels, sponges, cryogels, injectable hydrogels).
  • Discussion of HA's chemical properties relevant to scaffold design.

Main Results:

  • HA-based scaffolds can be fabricated into diverse forms including hydrogels, sponges, cryogels, and injectable formulations.
  • These scaffolds leverage HA's inherent biocompatibility and biodegradability.
  • Chemical modification allows for tailored scaffold properties.

Conclusions:

  • HA-based scaffolds offer significant potential for tissue engineering applications.
  • The choice of processing technique influences scaffold properties and suitability for specific tissues.
  • Further research into HA scaffold optimization can advance regenerative medicine.