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Estrogen-related receptor γ regulates expression of 17β-hydroxysteroid dehydrogenase type 1 in fetal growth

Hui Zhu1, Linhuan Huang1, Zhiming He1

  • 1Department of Obstetrics & Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Placenta
|June 27, 2018
PubMed
Abstract

Insights

Estrogen-related receptor γ (ERRγ) and 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) are lower in fetal growth restriction (FGR) placentae. ERRγ regulates HSD17B1, potentially contributing to FGR pathogenesis.

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Molecular genetics

Background:

  • Estrogen-related receptor γ (ERRγ) and 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) are implicated in cancer cell proliferation and invasion.
  • Their role in placental development and fetal growth restriction (FGR) is not well understood.

Purpose of the Study:

  • To investigate the expression of ERRγ and HSD17B1 in FGR placenta tissues.
  • To elucidate the molecular mechanism by which ERRγ regulates HSD17B1 in FGR development.

Main Methods:

  • Quantitative real-time PCR and Western blot analysis of placenta tissues from FGR and appropriate for gestational age (AGA) groups.
  • In vitro studies using HTR-8/SVneo trophoblast cells with ERRγ knockdown via siRNA.
  • Dual luciferase reporter assays to assess transcriptional regulation.

Main Results:

  • Both ERRγ and HSD17B1 mRNA and protein levels were significantly reduced in FGR placentae compared to AGA controls.
  • ERRγ knockdown in trophoblast cells inhibited proliferation and invasion, and decreased HSD17B1 expression.
  • ERRγ directly stimulated HSD17B1 transcription via an ERRγ response element in its promoter region.

Conclusions:

  • Aberrant expression of ERRγ and HSD17B1 may play a role in the pathogenesis of FGR.
  • ERRγ regulates HSD17B1 transcription, suggesting a novel molecular pathway involved in FGR development.
Keywords:
ERRγFetal growth restrictionHSD17B1Trophoblasts

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