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Helminth-Bacterial Interactions: Cause and Consequence.

Alexis Rapin1, Nicola L Harris2

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Intestinal helminths and gut microbes interact, influencing host health. This complex relationship can shift the balance, potentially benefiting the host or parasite, with significant impacts on the host

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Area of Science:

  • Microbiology
  • Parasitology
  • Immunology

Background:

  • Mammalian intestines host a complex ecosystem of helminths and microbes.
  • Evolutionary cohabitation suggests intricate interactions between these partners.
  • The 'ménage à trois' dynamic between host, helminth, and microbiome is crucial.

Purpose of the Study:

  • To investigate the impact of intestinal helminths on the mammalian gut microbiome.
  • To understand the consequences of these interactions for host and parasite.

Main Methods:

  • Analysis of host-helminth-microbiome interactions.
  • Review of recent scientific literature on helminth infections and gut microbiota.

Main Results:

  • Intestinal helminth infections significantly alter the gut microbiome composition.
  • These alterations can have varied consequences for the host's health and well-being.
  • The interactions can create an imbalance favoring either the host or the parasite.

Conclusions:

  • Helminth infection profoundly impacts the intestinal microbiome.
  • This tripartite relationship has significant implications for all involved partners.
  • Further research is needed to fully elucidate these complex interactions and their health outcomes.