SAR of the effect of endotoxin on serum angiotensin converting enzyme in the mouse

Administration of intact lipopolysaccharide from E. coli and S. minnesota to mice produced a lowering of serum angiotensin converting enzyme (ACE). However, when either lipid A or carbohydrate-free endotoxin from S. minnesota-Re595 was administered, a rise in serum ACE occurred. A possible explanation for these respective effects may be related to an indirect effect on lung perfusion, on the one hand, or a direct toxic effect to endothelial cell membranes, on the other.